Schizophrenia is (not simply) a neurodevelopmental disorder.

Developmental trajectory of cognitive impairment in bipolar disorder: comparison with schizophrenia.

Both schizophrenia and bipolar disorder (BP) are associated with neurocognitive deficits. However, it has been suggested that schizophrenia, but not BP, is characterised by premorbid cognitive impairments and neurodevelopmental abnormalities. In this paper, studies investigating neurocognitive deficits in premorbid, high-risk and first-episode BP were reviewed and these findings were compared w...

Neurodevelopmental factors associated with schizotypal symptoms among adolescents at risk for schizophrenia.

Schizophrenia has come to be viewed as a neurodevelopmental disorder that is characterized by genetic vulnerability, stressors during the prenatal period that may be marked by minor physical anomalies and neurobehavioral deficits that emerge in early development. Less is known about the neurodevelopmental origins of schizotypal personality symptoms. The present study examines schizotypal sympto...

Toxoplasmosis and its Relationship with Various Mental Disorders

Toxoplasmosis is a globally distributed disease caused by a parasitic protozoan called Toxoplasma gondii (T. gondii) in humans and animals that often develops asymptomatic acquired infections but the important aspect of this parasitic infection is the possible risk of congenital transmission and its severe effects on the fetus such as hydrocephalus, microcephaly, deafness and abortion up to mil...

Is schizophrenia a neurodevelopmental disorder?

Stereological analysis of cornu ammonis in prenatally stressed rats: a heuristic neurodevelopmental model of schizophrenia

Objective(s):The hippocampus has been implicated in pathophysiology of schizophrenia. Prenatal stress is a contributing risk factor for a wide variety of neuropsychiatric diseases including schizophrenia. This study examined long-term effects of prenatal restraint stress on the stereological parameters in the Cornu Ammonis (CA) of adult male rats as an animal model of schizophrenia. Materials ...